Research Papers (2020 - current)

Log D_7.4 and plasma protein binding of synthetic cannabinoid receptor agonists and a comparison of experimental and predicted lipophilicity, AM Brandon, SR Baginski, C Peet, P Dugard, H Green, OB Sutcliffe, N Nic Daeid, LA Nisbet, KD Read and C McKenzie, Drug Testing and Analysis (2023) DOI: https://doi.org/10.1002/dta.3621 (published online 08/12/2023).

Instant Detection of Synthetic Cannabinoids on Physical Matrices, Implemented on a Low-Cost, Ultraportable Device, GE Cozier, RC Andrews, A Frinculescu, R Kumar, B May, T Tooth, P Collins, A Costello, TSF Haines, TP Freeman, IS Blagrough, J Scott, T Shine, OB Sutcliffe, SM Husbands, J Leach, RW Bowman and CR Pudney, Analytical Chemistry (2023) DOI: https://doi.org/10.1021/acs.analchem.3c01844 (published online 29/08/2023).

Synthesis, characterisation and quantification of the new psychoactive substance 1-(1,3-benzodioxol-5-yl)-2-(propylamino)butan-1-one (bk-PBDB, putylone), DI Dixon, MF Millea, ATM Wilcock, A Costello, JR Ellison, S Lord, KA O’Brien, RE Mewis and OB Sutcliffe, Forensic Chemistry (2023) DOI: https://doi.org/10.1016/j.forc.2023.100523 (published online 10/08/2023).

Synthetic Cannabinoid Receptor Agonists are Monoamine Oxidase-A Selective Inhibitors, SA Hindson, R Andrews, MJ Danson, MW van der Kamp, AE Manley, OB Sutcliffe, TSF Haines, T Freeman, J Scott, S Husbands, I Blagborough, JL Ross Anderson, D Carbery and C Pudney, The FEBS Journal (2023) DOI: https://doi.org/10.1111/febs.16741 (published online: 28/01/2023).

Photochemical fingerprinting is a sensitive probe for the detection of synthetic cannabinoid receptor agonists; towards robust point-of-care detection, R Andrews, B May, FJ Hernández, GE Cozier, P Townsend, OB Sutcliffe, T Haines, T Freeman, J Scott, S Husbands, I Blagborough, R Bowman, S Lewis, M Grayson, R Crespo-Otero, D Carbery and C Pudney, Analytical Chemistry (2023), 95 (2), 703–713.

Non-invasive in vivo assessment of 11β-hydroxysteroid dehydrogenase type 1 activity by 19F-Magnetic Resonance Spectroscopy, G Naredo-Gonzalez, R Upreti, MA Jansen, S Semple, OB Sutcliffe, I Marshall, BR Walker and R Andrew, Nature: Scientific Reports (2022), 12(1), 16268.

3,4-Methylenedioxymethamphetamine quantification via benchtop ¹H qNMR spectroscopy: method validation and its application to ecstasy tablets collected at music festivals, OB Sutcliffe, RE Mewis, EK Kemsley and D Williamson, Journal of Pharmaceutical and Biomedical Analysis (2022), 221, 115042.

Comparative study of the analysis of seized samples by GC-MS, ¹H NMR and FT-IR spectroscopy within a Night-Time Economy (NTE) setting, DI Dixon, LH Antonides, A Costello, B Crane, A Embleton, ML Fletcher, N Gilbert, MC Hulme, MJ James, MA Lever, CJ Maccallum, MF Millea, JL Pimlott, TBR Robertson, NE Rudge, CJ Schofield, F Zukowicz, EK Kemsley, OB Sutcliffe and RE Mewis, Journal of Pharmaceutical and Biomedical Analysis (2022), 219, 114950.

Guilty by Dissociation: Part B: Evaluation of Supercritical Fluid Chromatography (SFC-UV) for the analysis of regioisomeric diphenidine-derived Novel Psychoactive Substances (NPS). G Cochrane, JK Field, MC Hulme, N Gilbert, RE Mewis, MR Euerby and OB Sutcliffe, Journal of Pharmaceutical and Biomedical Analysis (2022), 216, 114797.

Guilty by Dissociation: Part A: Development of a rapid Ultra-High Performance Liquid Chromatography (UHPLC)-MS/MS methodology for the analysis of regioisomeric diphenidine-derived Novel Psychoactive Substances (NPS), JK Field, C Hinz, CM Titman, MC Hulme, RM Cowan, JB Ainsworth-McMillan, N Gilbert, RJ Lee, J Marron, A Costello, RE Mewis, MR Euerby and OB Sutcliffe, Journal of Pharmaceutical and Biomedical Analysis (2022), 216, 114798.

The metabolism of the synthetic cannabinoids ADB-BUTINACA and ADB-4en-PINACA and their detection in forensic toxicology casework and infused papers seized in prisons, R Kronstrand, C Norman, S Vikingsson, A Biemans, B Valencia Crespo, D Edwards, D Fletcher, N Gilbert, M Persson, R Reid, O Semenova, F Al Teneiji, X Wu, J Dahlén, N NicDaeid, F Tarbah, OB Sutcliffe, C McKenzie and H Gréen, Drug Testing and Analysis (2021), 1-19.

Lab-on-a-Chip approaches for the detection of controlled drugs, including new psychoactive substances: A systematic review, L McNeill, D Megson, PE Linton, J Norrey, L Bradley, OB Sutcliffe and KJ Shaw, Forensic Chemistry (2021), 26, 100370.

Hyperpolarisation of Mirfentanil by SABRE in the presence of heroin, TBR Robertson, N Gilbert, OB Sutcliffe and RE Mewis, ChemPhysChem (2021), 22, 1059.

Detection, discrimination and quantification of amphetamine, cathinone and nor-ephedrine regioisomers using benchtop ¹H- and ¹⁹F-NMR spectroscopy, MC Hulme, A Hayatbaksh, RM Brignall, N Gilbert, A Costello, CJ Schofield, DC Willamson, EK Kemsley, OB Sutcliffe and RE Mewis, Magn Reson Chem.  (2021), 1-10. https://doi.org/10.1002/mrc.5156

Fast & Fluorinated – Development and validation of a rapid benchtop NMR approach and other routine screening methods for the detection and quantification of synthesised fluorofentanyl derivatives, N Gilbert, RE Mewis and OB Sutcliffe, Forensic Chemistry (2021), 23, 100321.

Origami Chips: Development and validation of a paper-based Lab-on-a-Chip device for the rapid and cost-effective detection of 4-methylmethcathinone (mephedrone) and its metabolite, 4-methylephedrine in urine, L McNeill, C Pearson, D Megson, J Norrey, D Watson, D Ashworth, PE Linton, OB Sutcliffe and KJ Shaw, Forensic Chemistry (2021), 22, 100293.

Shape Matters: The application of activity-based in-vitro bioassays and chiral profiling to the pharmacological evaluation of synthetic cannabinoid receptor agonists in drug-infused papers seized in prisons, LH Antonides, A Cannaert, C Norman, N Nic Daeid, OB Sutcliffe, CP Stove and C McKenzie, Drug Testing and Analysis (2020), 1-16.

Classification of fentanyl analogues through principal component analysis (PCA) and hierarchical clustering of GC–MS data, N Gilbert, RE Mewis and OB Sutcliffe, Forensic Chemistry (2020), 21, 100287.

Quantification of MDMA in seized tablets using benchtop ¹H NMR spectroscopy in the absence of internal standards, JH Hussain, N Gilbert, A Costello, CJ Schofield, EK Kemsley, OB Sutcliffe and RE Mewis, Forensic Chemistry (2020), 20, 100263.

Hitting the Jackpot - Development of Gas Chromatography-Mass Spectrometry (GC-MS) and other rapid screening methods for the analysis of 18 fentanyl-derived synthetic opioids, N Gilbert, LH Antonides, CJ Schofield, A Costello, B Kilkelly, AR Cain, PRV Dalziel, K Horner, RE Mewis and OB Sutcliffe, Drug Testing and Analysis (2020), 12, 798-811.

Benchtop NMR analysis of piperazine-based drugs hyperpolarised by SABRE, T Tennant, MC Hulme, TBR Robertson, OB Sutcliffe and RE Mewis, Magnetic Resonance in Chemistry (2020), 1–9.

Detection and quantification of synthetic cannabinoid receptor agonists in infused papers from prisons in a constantly evolving illicit market, C Norman, G Walker, B McKirdy, C McDonald, D Fletcher, LH Antonides, OB Sutcliffe, N Nic Daeid and C McKenzie, Drug Testing and Analysis (2020), 12, 538–554.