Research Papers (2000 - 2009)

PAMAM dendrimers as drug delivery vehicles for platinum anticancer drugs, GJ Kirkpatrick, OB Sutcliffe, DJ Flint, NJ Wheate, Journal of Biological Inorganic Chemistry (2009), 14 (1), 125.

Synthesis of aromatase inhibitors and dual aromatase-sulfatase inhibitors by linking an arylsulfamate motif to 4-(4H-1,2,4-triazol-4-ylamino)benzonitrile: SAR, crystal structures, in vitro and in vivo activities, C Bubert, LWL Woo, OB Sutcliffe, MF Mahon, SK Chander, A Purohit, MJ Reed, BVL Potter, ChemMedChem (2008), 3, 1708–1730.

A new therapeutic strategy against hormone-dependent breast cancer: The pre-clinical development of a dual aromatase and sulfatase inhibitor (DASI), PA Foster, SK Chander, SP Newman, R Jhalli, OB Sutcliffe, CA Bubert, LWL Woo, S Chen, BVL Potter, MJ Reed, A Purohit, Clin Cancer Res (2008), 14, 6469–6477.

Dual aromatase-steroid sulfatase inhibitors , LWL Woo, C Bubert, OB Sutcliffe, A Smith, SK Chander, MF Mahon, A Purohit, MJ Reed, BVL Potter, J. Med. Chem. (2007), 50 (15) 3540–3560.

First crystal structures of human carbonic anhydrase II in complex with dual aromatase-steroid sulfatase inhibitors, MD Lloyd, N Thiyagarajan, YT Ho, LWL Woo, OB Sutcliffe, A Purohit, MJ Reed, KR Acharya, BVL Potter, Biochemistry (2005), 44 (18), 6858–6866.

Planar chiral 2-ferrocenyloxazolines and 1,1’-bis(oxazolinyl)ferrocenes – syntheses and applications in asymmetric catalysis, OB Sutcliffe, MR Bryce, Tetrahedron: Asymmetry (2003), 14 (16), 2297–2325.

First dual aromatase-steroid sulfatase inhibitors, LWL Woo, OB Sutcliffe, C Bubert, A Grasso, SK Chander, A Purohit, MJ Reed and BVL Potter, J. Med. Chem. (2003), 46 (15), 3193–3196.

Synthesis of novel chiral bis(ferrocenyl) ligands and their use as voltammetric metal cation sensors, OB Sutcliffe, MR Bryce, AS Batsanov, J. Organomet. Chem. (2002), 656 (1–2), 211–216.

Azafulvenium methides: new extended dipolar systems, OB Sutcliffe, RC Storr, TL Gilchrist, P Rafferty, J. Chem. Soc. (Perkin Trans. 1) (2001), 15, 1795–1806.

Voltammetric metal cation sensors based on ferrocene derivatives with oxazoline and imine substituents, OB Sutcliffe, A Chesney, MR Bryce, J. Organomet. Chem. (2001), 637, 134–138.

Cycloadditions to pyrrolo[1,2-c]thiazoles and pyrazolo[1,5-c]thiazoles, OB Sutcliffe, RC Storr, TL Gilchrist, P Rafferty, Tetrahedron (2000), 56 (51), 10011–10021.

Azafulvenium methides: new extended dipolar systems, OB Sutcliffe, RC Storr, TL Gilchrist, P Rafferty, APA Crew, Chemical Communications (2000), 8, 675–676.