Sutcliffe Research Group
Sutcliffe Research Group

Research Papers (2010 - Current)

Inhibitory Kappa-B-kinse-α (IKKα) inhibitors that recapitulate their selectivity in cells against isoform-related biomarkers, NG Anthony, J Baiget, G Berretta, M Boyd, D Breen, J Edwards, C Gamble, AI Gray, AL Harvey, S Hatziieremia, KH Ho, JK Huggan, S Lang, S Llona-Minguez, JL Luo, K McIntosh, A Paul, RJ Plevin, MN Robertson, R Scott, CJ Suckling, OB Sutcliffe, LC Young, Mackay SP, J. Med. Chem. (2017), in press.

 

Development of a novel flexible polymer-based biosensor platform for the thermal detection of noradrenaline in aqueous solutions, S Casadio, JW Lowdon, K Betlem, J Tadashi, CW Foster, TJ Cleidj, B van Grinsven, OB Sutcliffe, CE Banks, M Peeters, Chem Eng. J. (2017), 315, 459-468.

 

Ball mill and microwave assisted synthetic routes to Fluoxetine, R Solà, OB Sutcliffe, CE Banks, B Maciá, Sustainable Chemistry and Pharmacy  (2017), 5, 14-21.

 

Identification of novel metabolic pathways of Sitagliptin (STG) by LC/MS and LC/MS2 after incubations with rat hepatocytes, OIG Khreit, HM Grant, C Henderson, DG Watson and OB Sutcliffe, Journal of Drug Metabolism & Toxicology (2016), 7, 4, 220. DOI:10.4172/2157-7609.1000220

 

Guilty by Dissociation - Development of gas chromatography mass spectrometry (GC-MS) and other rapid screening methods for the analysis of 13 diphenidine-derived new psychoactive substances (NPSs), PM Geyer, MC Hulme, JPB Irving, PD Thompson, RN Ashton, RJ Lee, L Johnson, J Marron, CE Banks, OB Sutcliffe, Anal. Bioanal. Chem. (2016), 408 (29), 8467-8481.

 

Forensic electrochemistry: simultaneous voltammetric detection of MDMA and its fatal counterpart “Dr Death” (PMA), LR Cumba, JP Smith, KY Zuway, OB Sutcliffe, DR do Carmo, CE Banks, Analytical Methods (2016), 8 (1), 142-152.

 

Regal electrochemistry: sensing of the synthetic cathinone class of new psychoactive substances (NPSs), F Tan, JP Smith, OB Sutcliffe, CE Banks, Analytical Methods (2015), 7 (16), 6470–6474.

 

Detection and quantification of new psychoactive substances (NPSs) within the evolved “legal high” product, NRG-2, using high performance liquid chromatography-amperometric detection (HPLC-AD), KY Zuway, JP Smith, CW Foster, N Kapur, CE Banks, OB Sutcliffe, Analyst (2015), 140 (18), 6283-6294.

 

Forensic electrochemistry: indirect electrochemical sensing of the components of the new psychoactive substance “Synthacaine”, LR Cumba, AV Kolliopoulos, JP Smith, PD Thompson, PR Evans, OB Sutcliffe, DR do Carmo, CE Banks, Analyst (2015), 140 (16), 5536-5545.

 

An overview of recent developments in the analytical detection of new psychoactive substances (NPSs), JP Smith, OB Sutcliffe, CE Banks, Analyst (2015), 140 (15), 4932–4948.

 

The Ecstasy and the agony; compression studies of 3,4-methylenedioxymethamphetamine (MDMA), LE Connor, A Delori, IB Hutchinson, N Nic Daeid, OB Sutcliffe, IDH Oswald, Acta Crystallographica Section B: Structural Science (2015), 71 (1), 3-9.

 

Chromatographic and spectroscopic analysis of the components present in the phenanthridinium trypanocidal agent isometamidium, JO Igoli, G Blackburn, AI Gray, OB Sutcliffe, DG Watson, MR Euerby, GG Skellern, Analytical and Bioanalytical Chemistry (2014), 407 (4), 1171-1180.

 

Metallic impurities in graphene screen-printed electrodes can influence their electrochemical properties, JP Smith, CW Foster, JP Metters, OB Sutcliffe, CE Banks, Electroanalysis (2014), 26 (11), 2429-2433.

 

Forensic electrochemistry applied to the sensing of New Psychoactive Substances: Electroanalytical sensing of synthetic cathinones and analytical validation in the quantification of seized street samples, JP Smith, JP Metters, OIG Khreit, OB Sutcliffe, CE Banks, Analytical Chemistry (2014), 86(19), 9985-9992.

 

Amide coupling reaction for the synthesis of bis-pyridine-based ligands and their complexation to platinum as dinuclear anticancer agents, MG Apps, BW Johnson, OB Sutcliffe, SD Brown, NJ Wheate, Journal of Visualized Experiments (2014), (87), e51740/1-e51740/7, 7.

 

Animal trypanosomosis: making quality control of trypanocidal drugs possible, OB Sutcliffe, GG Skellern, F Araya, A Cannavan, JJ Sasanya, B Dungu, F van Gool, S Munstermann, RC Mattioli, Revue Scientifique et Technique-Office International des Epizooties (2014), 33 (3), 813-830.

 

A comparison of silica C and silica gel in HILIC mode: The effect of stationary phase surface area, EY Santali, D Edwards, OB Sutcliffe, S Bailes, MR Euerby, DG Watson, Chromatographia (2014), 77(13-14), 873-881.

 

Development of gas chromatography-mass spectrometry (GC-MS) and other rapid screening methods for the analysis of 16 'legal high' cathinone derivatives, N Nic Daeid, KA Savage, D Ramsay, C Holland, OB Sutcliffe, Science & Justice (2014), 54(1), 22-31.

 

Drug solid solutions - a method for tuning phase transformations, A Delori, P Maclure, RM Bhardwaj, A Johnston, AJ Florence, OB Sutcliffe, IDH Oswald, CrystEngComm (2014), 16(26), 5827-5831.

 

Forensic electrochemistry: the electroanalytical sensing of synthetic cathinone-derivatives and their accompanying adulterants in "legal high" products, JP Smith, JP Metters, C Irving, OB Sutcliffe, CE Banks, Analyst (2014), 139(2), 389-400.

 

Putting the squeeze on mephedrone hydrogen sulfate, N Satthaphut, OB Sutcliffe, IDH Oswald, Zeitschrift fuer Kristallographie - Crystalline Materials (2014), 229(2), 101-111.

 

Forensic electrochemistry: the electroanalytical sensing of Rohypnol (flunitrazepam) using screen-printed graphite electrodes without recourse for electrode or sample pre-treatment, JP Smith, JP Metters, DK Kampouris, C Lledo-Fernandez, OB Sutcliffe, CE Banks, Analyst (2013), 138(20), 6185-6191.

 

Elucidation of the Phase I and Phase II metabolic pathways of (±)-4'-methylmethcathinone (4-MMC) and (±)-4'-(trifluoromethyl)methcathinone (4-TFMMC) in rat liver hepatocytes using LC-MS and LC-MS2, OIG Khreit, MH Grant, T Zhang, C Henderson, DG Watson, OB Sutcliffe, Journal of Pharmaceutical and Biomedical Analysis (2013), 72, 177-185.

 

A comparison of the chromatographic properties of silica gel and silicon hydride modified silica gels, S Bawazeer, OB Sutcliffe, MR Euerby, S Bawazeer and DG Watson, J. Chromatogr. A, (2012), 1263, 61-67.

 

A validated stability-indicating HPLC method for routine analysis of an injectable lincomycin and spectinomycin formulation, MN Abulalhasan, N Batrawi, OB Sutcliffe and AN Zaid, Scientia Pharmaceutica (2012), 80, 977-986.

 

Combining aspects of the platinum anticancer drugs picoplatin and BBR3464 to synthesize a new family of sterically hindered dinuclear complexes; their synthesis, binding kinetics and cytotoxicity, SD Brown, KD Trotter, OB Sutcliffe, JA Plumb, B Wadell, NEB Briggs and NJ Wheate, Dalton Transactions (2012), 41, 11330-11339.

 

Doing the methylene shuffle - Further insights into the inhibition of mitotic kinesin Eg5 with S-trityl L-cysteine, MN Abualhasan, JAD Good, K Wittayanarakul, NG Anthony, G Berretta, O Rath, F Kozielski, OB Sutcliffe and SP Mackay, European Journal of Medicinal Chemistry (2012), 54, 483-498.

 

Using isotopic fractionation to link precursor to product in the synthesis of (±)-mephedrone: A new tool for combating "Legal High" drugs, N Nic Daeid, W Meier-Augenstein, HF Kemp, OB Sutcliffe, Analytical Chemistry (2012), 84(20), 8691-8696.

 

Triphenylbutanamines - Kinesin Spindle Protein inhibitors with in vivo anti-tumour activity, F Wang, JA Good, O Rath, HY Kaan, OB Sutcliffe, SP Mackay SP, F Kozielski, J. Med. Chem. (2012), 55, 1511-1525.

 

Synthesis, full chemical characterisation and development of validated methods for the quantification of the components found in the evolved "legal high" NRG-2, OIG Khreit, C Irving, E Schmidt, JA Parkinson, N Nic Daeid, OB Sutcliffe, Journal of Pharmaceutical and Biomedical Analysis (2012), 61, 122-135.

 

Manganese dioxide mediated one-pot synthesis of methyl 9H-pyrido[3,4-b]indole-1-carboxylate: Concise synthesis of alangiobussinine, J Baiget, S Llona-Minguez, S Lang, SP Mackay, CJ Suckling, OB Sutcliffe, Beilstein J Org Chem. (2011), 7, 1407-1411.

 

Structure-activity relationship for the first-in-class clinical steroid sulfatase inhibitor Irosustat (STX64, BN83495), LWL Woo, D Ganeshapillai, MP Thomas, OB Sutcliffe, B Malini, MF Mahon, A Purohit, BVL Potter, ChemMedChem (2011), 6(11), 2019-2034.

 

Evaluation of anionic half generation 3.5-6.5 poly(amidoamine) dendrimers as delivery vehicles for the active component of the anticancer drug cisplatin, GJ Kirkpatrick, JA Plumb, OB Sutcliffe, DJ Flint, NJ Wheate, Journal of Inorganic Biochemistry (2011), 105(9), 1115-1122.

 

Synthesis and full chemical characterisation of (±)-4'-methylmethcathinone (mephedrone): A new "legal high", EY Santali, A-K Cadogan, N Nic Daeid, KA Savage, OB Sutcliffe, Journal of Pharmaceutical and Biomedical Analysis (2011), 56(2), 246-255.

 

Non-invasive in-vivo monitoring of 11 beta-HSD1 activity using F-19-magnetic resonance spectroscopy, G Naredo-Gonzalez, MA Jansen, GD Merrifield, OB Sutcliffe, MK Hansen, R Andrew, BR Walker, Endocrine Reviews (2010), 31(3, Suppl 1). 

 

Design and synthesis of novel Eg5 inhibitors, M Abulalhasan, OB Sutcliffe, F Kozielski, SP Mackay, Journal of Pharmacy & Pharmacology (2010), 62(10), 1367.

 

The Drug Discovery Portal: A computational platform for identifying drug leads from academia, RL Clark, BF Johnston, SP Mackay, CJ Breslin, MN Robertson, MJ Dufton, OB Sutcliffe, AL Harvey, Current Pharmaceutical Design (2010), 16(15), 1697–1702.

 

Microwave synthesis of curcurbit[n]urils, NJ Wheate, N Patel, OB Sutcliffe, Future Medicinal Chemistry (2010), 2, 231–236.

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